Effect of dietary Senecio jacobaea and injected Senecio alkaloids and monocrotaline on guinea pigs.

Evaluation of amino acids, B vitamins and butylated hydroxyanisole as protective agents against pyrrolizidine alkaloid toxicity in rats.

Supplementation of the diets of rats with branched chain amino acids (BCAA: leucine, isoleucine, valine) did not alter their susceptibility to chronic poisoning by tansy ragwort (Senecio jacobaea), which contains hepatotoxic pyrrolizidine alkaloids (PA). Phenobarbital in the diet, which alters liver microsomal enzyme activity, also did not alter susceptibility to PA poisoning. A combination of ...

Factors Influencing Pyrroliz Id Ine (senecio) Alkaloid Metabolism: Species, Liver Sulfhydryls and Rumen Fermentation 1

The metabolism in vitro of pyrrolizidine alkaloids by microsomes from eight animal species was studied. The rates of pyrrole production ranged from high to low in the following order: male hamster > male rabbit > male mouse > male rat > beef steer > beef bull female rat > wether lamb > male chicken male Japanese quail. With the exception of the rabbit and chicken, there appeared to be a direct ...

Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): implications for toxicity. Phytochemistry 108: 137-146 DOI 10.1016/j.phytochem.2014.06.006 Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): implications for toxicity

Alkaloids from the roots of Senecio macedonicus Griseb.

The new alkaloids 7-,9-diangeloylplatynecine (1) and 8-episarracine N-oxide (2), were isolated and identified from the roots of Senecio macedonicus. Another one, 8-epineosarracine was detected by GC/MS analyses of the crude alkaloid mixture. The cytotoxicity and biological activity of the alkaloids were tested on normal murine spleen lymphocytes and P3U1 mouse myeloma.

Natural hybridization between Senecio jacobaea and Senecio aquaticus: molecular and chemical evidence.

Hybridization is known to be involved in a number of evolutionary processes, including species formation, and the generation of novel defence characteristics in plants. The genus Senecio of the Asteraceae family is highly speciose and has historically demonstrated significant levels of interspecific hybridization. The evolution of novel chemical defence characteristics may have contributed to t...